Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Burton | 0 | 0 | Oxford | C Pawson |
| 14/08/2010 | Oxford | 1 | 2 | Bury | S Tanner |
| 21/08/2010 | Wycombe | 0 | 0 | Oxford | A Taylor |
| 28/08/2010 | Oxford | 0 | 0 | Accrington | M Naylor |
| 04/09/2010 | Oxford | 4 | 0 | Morecambe | B Malone |
| 11/09/2010 | Hereford | 0 | 2 | Oxford | R Lewis |
| 18/09/2010 | Oxford | 0 | 1 | Stockport | C Boyeson |
| 25/09/2010 | Crewe | 1 | 1 | Oxford | G Eltringham |
| 28/09/2010 | Cheltenham | 1 | 1 | Oxford | S Rushton |
| 02/10/2010 | Oxford | 2 | 1 | Port Vale | G Ward |
| 09/10/2010 | Oxford | 0 | 1 | Aldershot | A Bates |
| 16/10/2010 | Macclesfield | 3 | 2 | Oxford | K Evans |
| 23/10/2010 | Oxford | 3 | 1 | Northampton | P Tierney |
| 30/10/2010 | Bradford | 5 | 0 | Oxford | D Webb |
| 02/11/2010 | Oxford | 0 | 2 | Torquay | D Sheldrake |
| 13/11/2010 | Rotherham | 2 | 1 | Oxford | D Drysdale |
| 20/11/2010 | Oxford | 0 | 1 | Gillingham | S Mathieson |
| 23/11/2010 | Chesterfield | 1 | 2 | Oxford | G Horwood |
| 04/12/2010 | Oxford | 2 | 1 | Barnet | R Madley |
| 28/12/2010 | Oxford | 2 | 1 | Macclesfield | R Lewis |
| 01/01/2011 | Oxford | 0 | 2 | Southend | C Sarginson |
| 03/01/2011 | Torquay | 3 | 4 | Oxford | R East |
| 08/01/2011 | Aldershot | 1 | 2 | Oxford | O Langford |
| 15/01/2011 | Oxford | 2 | 1 | Bradford | D Phillips |
| 22/01/2011 | Northampton | 2 | 1 | Oxford | A Marriner |
| 25/01/2011 | Oxford | 3 | 1 | Shrewsbury | S Tanner |
| 29/01/2011 | Oxford | 1 | 1 | Cheltenham | G Horwood |
| 01/02/2011 | Southend | 2 | 1 | Oxford | K Hill |
| 05/02/2011 | Gillingham | 0 | 0 | Oxford | G Hegley |
| 12/02/2011 | Oxford | 2 | 1 | Rotherham | S Hooper |
| 15/02/2011 | Stevenage | 0 | 0 | Oxford | P Crossley |
| 19/02/2011 | Morecambe | 0 | 3 | Oxford | P Gibbs |
| 26/02/2011 | Oxford | 0 | 2 | Hereford | D Drysdale |
| 01/03/2011 | Lincoln | 3 | 1 | Oxford | G Eltringham |
| 05/03/2011 | Stockport | 2 | 1 | Oxford | R Shoebridge |
| 12/03/2011 | Port Vale | 1 | 2 | Oxford | P Tierney |
| 15/03/2011 | Oxford | 1 | 2 | Stevenage | M Haywood |
| 19/03/2011 | Oxford | 2 | 1 | Crewe | C Boyeson |
| 27/03/2011 | Oxford | 3 | 0 | Burton | D McDermidd |
| 02/04/2011 | Bury | 3 | 0 | Oxford | D Coote |
| 09/04/2011 | Oxford | 2 | 2 | Wycombe | D Deadman |
| 16/04/2011 | Accrington | 0 | 0 | Oxford | C Webster |
| 23/04/2011 | Oxford | 0 | 0 | Chesterfield | G Salisbury |
| 25/04/2011 | Barnet | 2 | 2 | Oxford | D Whitestone |
| 30/04/2011 | Oxford | 2 | 1 | Lincoln | B Malone |
| 07/05/2011 | Shrewsbury | 3 | 0 | Oxford | P Tierney |