Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Tranmere | 1 | 2 | Oldham | G Salisbury |
| 14/08/2010 | Oldham | 3 | 0 | Notts County | C Webster |
| 21/08/2010 | Charlton | 1 | 1 | Oldham | R Shoebridge |
| 28/08/2010 | Oldham | 0 | 0 | Yeovil | O Langford |
| 04/09/2010 | Oldham | 1 | 1 | Bristol Rvs | G Eltringham |
| 11/09/2010 | Peterboro | 5 | 2 | Oldham | G Horwood |
| 18/09/2010 | Oldham | 2 | 1 | Bournemouth | C Pawson |
| 25/09/2010 | Brighton | 2 | 1 | Oldham | A Penn |
| 28/09/2010 | Sheffield Weds | 0 | 0 | Oldham | D Webb |
| 02/10/2010 | Oldham | 1 | 1 | Leyton Orient | R Madley |
| 09/10/2010 | Brentford | 1 | 3 | Oldham | K Stroud |
| 16/10/2010 | Oldham | 0 | 0 | Colchester | P Quinn |
| 23/10/2010 | Southampton | 2 | 1 | Oldham | A D'Urso |
| 30/10/2010 | Oldham | 4 | 2 | Plymouth | E Ilderton |
| 13/11/2010 | Oldham | 1 | 0 | Huddersfield | S Hooper |
| 20/11/2010 | Dag and Red | 0 | 1 | Oldham | K Wright |
| 23/11/2010 | Oldham | 3 | 3 | Exeter | D Coote |
| 27/11/2010 | Rochdale | 1 | 1 | Oldham | A Bates |
| 01/01/2011 | Hartlepool | 4 | 2 | Oldham | A Haines |
| 03/01/2011 | Oldham | 1 | 2 | Rochdale | A Taylor |
| 08/01/2011 | Oldham | 2 | 0 | Swindon | D Drysdale |
| 11/01/2011 | Oldham | 0 | 6 | Southampton | G Eltringham |
| 15/01/2011 | Plymouth | 0 | 2 | Oldham | P Miller |
| 22/01/2011 | Oldham | 2 | 1 | Brentford | C Sarginson |
| 25/01/2011 | Walsall | 1 | 1 | Oldham | R East |
| 29/01/2011 | Carlisle | 2 | 2 | Oldham | C Pawson |
| 01/02/2011 | Oldham | 4 | 0 | Hartlepool | P Tierney |
| 05/02/2011 | Oldham | 1 | 1 | Dag and Red | S Rushton |
| 12/02/2011 | Huddersfield | 0 | 0 | Oldham | A Woolmer |
| 15/02/2011 | Oldham | 0 | 1 | Carlisle | M Haywood |
| 19/02/2011 | Bristol Rvs | 1 | 0 | Oldham | P Crossley |
| 22/02/2011 | Milton Keynes Dons | 0 | 0 | Oldham | I Williamson |
| 26/02/2011 | Oldham | 0 | 5 | Peterboro | D Foster |
| 05/03/2011 | Bournemouth | 3 | 0 | Oldham | L Mason |
| 08/03/2011 | Oldham | 2 | 3 | Sheffield Weds | E Ilderton |
| 12/03/2011 | Leyton Orient | 1 | 0 | Oldham | R Lewis |
| 19/03/2011 | Oldham | 0 | 1 | Brighton | D Whitestone |
| 22/03/2011 | Colchester | 1 | 0 | Oldham | J Linnington |
| 28/03/2011 | Oldham | 0 | 0 | Tranmere | A Bates |
| 02/04/2011 | Notts County | 0 | 2 | Oldham | R Madley |
| 09/04/2011 | Oldham | 0 | 0 | Charlton | K Wright |
| 16/04/2011 | Yeovil | 1 | 1 | Oldham | T Kettle |
| 22/04/2011 | Exeter | 2 | 0 | Oldham | J Waugh |
| 25/04/2011 | Oldham | 1 | 1 | Walsall | D Drysdale |
| 30/04/2011 | Swindon | 0 | 2 | Oldham | M Naylor |
| 07/05/2011 | Oldham | 1 | 2 | Milton Keynes Dons | P Gibbs |