Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Torquay | 3 | 0 | Northampton | O Langford |
| 14/08/2010 | Northampton | 0 | 0 | Accrington | P Crossley |
| 21/08/2010 | Bury | 1 | 1 | Northampton | A Bates |
| 28/08/2010 | Northampton | 1 | 1 | Wycombe | C Boyeson |
| 04/09/2010 | Aldershot | 1 | 1 | Northampton | G Scott |
| 11/09/2010 | Northampton | 2 | 1 | Southend | M Haywood |
| 18/09/2010 | Shrewsbury | 3 | 1 | Northampton | M Naylor |
| 25/09/2010 | Northampton | 2 | 0 | Bradford | P Gibbs |
| 28/09/2010 | Northampton | 1 | 2 | Chesterfield | A D'Urso |
| 02/10/2010 | Macclesfield | 2 | 0 | Northampton | R Booth |
| 09/10/2010 | Cheltenham | 1 | 0 | Northampton | D Phillips |
| 16/10/2010 | Northampton | 3 | 4 | Hereford | D Deadman |
| 23/10/2010 | Oxford | 3 | 1 | Northampton | P Tierney |
| 30/10/2010 | Northampton | 2 | 1 | Gillingham | R Shoebridge |
| 02/11/2010 | Lincoln | 0 | 2 | Northampton | M Brown |
| 13/11/2010 | Northampton | 0 | 0 | Port Vale | I Williamson |
| 20/11/2010 | Barnet | 4 | 1 | Northampton | S Tanner |
| 23/11/2010 | Rotherham | 2 | 2 | Northampton | R Lewis |
| 04/12/2010 | Northampton | 2 | 0 | Stockport | J Moss |
| 11/12/2010 | Stevenage | 0 | 1 | Northampton | G Horwood |
| 01/01/2011 | Crewe | 2 | 0 | Northampton | C Pawson |
| 03/01/2011 | Northampton | 2 | 1 | Lincoln | G Hegley |
| 08/01/2011 | Northampton | 1 | 1 | Cheltenham | S Rushton |
| 15/01/2011 | Gillingham | 1 | 0 | Northampton | T Kettle |
| 22/01/2011 | Northampton | 2 | 1 | Oxford | A Marriner |
| 01/02/2011 | Northampton | 6 | 2 | Crewe | A Madley |
| 05/02/2011 | Northampton | 0 | 0 | Barnet | D Coote |
| 12/02/2011 | Port Vale | 1 | 1 | Northampton | B Malone |
| 15/02/2011 | Northampton | 3 | 3 | Morecambe | R Madley |
| 19/02/2011 | Northampton | 1 | 1 | Aldershot | K Evans |
| 22/02/2011 | Hereford | 1 | 1 | Northampton | K Hill |
| 26/02/2011 | Southend | 1 | 1 | Northampton | R Booth |
| 01/03/2011 | Northampton | 2 | 3 | Burton | P Miller |
| 05/03/2011 | Northampton | 2 | 3 | Shrewsbury | T Kettle |
| 08/03/2011 | Chesterfield | 2 | 1 | Northampton | P Quinn |
| 12/03/2011 | Northampton | 0 | 1 | Macclesfield | G Eltringham |
| 19/03/2011 | Bradford | 1 | 1 | Northampton | R Lewis |
| 25/03/2011 | Northampton | 2 | 2 | Torquay | C Sarginson |
| 02/04/2011 | Accrington | 3 | 1 | Northampton | P Gibbs |
| 05/04/2011 | Burton | 1 | 1 | Northampton | D Drysdale |
| 09/04/2011 | Northampton | 2 | 4 | Bury | J Linington |
| 16/04/2011 | Wycombe | 2 | 2 | Northampton | P Crossley |
| 22/04/2011 | Northampton | 2 | 2 | Rotherham | K Stroud |
| 25/04/2011 | Stockport | 2 | 2 | Northampton | N Miller |
| 30/04/2011 | Northampton | 2 | 0 | Stevenage | P Tierney |
| 07/05/2011 | Morecambe | 1 | 2 | Northampton | A Haines |