Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Middlesbrough | 1 | 3 | Ipswich | T Bates |
| 14/08/2010 | Leicester | 0 | 0 | Middlesbrough | M Jones |
| 22/08/2010 | Middlesbrough | 1 | 0 | Sheffield United | D Whitestone |
| 28/08/2010 | Barnsley | 2 | 0 | Middlesbrough | K Hill |
| 11/09/2010 | QPR | 3 | 0 | Middlesbrough | M Russell |
| 14/09/2010 | Middlesbrough | 2 | 1 | Burnley | J Moss |
| 18/09/2010 | Middlesbrough | 3 | 1 | Reading | G Salisbury |
| 25/09/2010 | Watford | 3 | 1 | Middlesbrough | F Graham |
| 28/09/2010 | Derby | 3 | 1 | Middlesbrough | C Pawson |
| 02/10/2010 | Middlesbrough | 2 | 2 | Portsmouth | R Shoebridge |
| 16/10/2010 | Middlesbrough | 1 | 2 | Leeds | C Foy |
| 19/10/2010 | Nott'm Forest | 1 | 0 | Middlesbrough | S Tanner |
| 23/10/2010 | Norwich | 1 | 0 | Middlesbrough | J Linington |
| 30/10/2010 | Middlesbrough | 1 | 2 | Bristol City | C Boyeson |
| 06/11/2010 | Middlesbrough | 2 | 1 | Crystal Palace | M Haywood |
| 09/11/2010 | Scunthorpe | 0 | 2 | Middlesbrough | K Wright |
| 14/11/2010 | Swansea | 1 | 0 | Middlesbrough | K Hill |
| 20/11/2010 | Middlesbrough | 0 | 1 | Millwall | T Kettle |
| 27/11/2010 | Middlesbrough | 2 | 2 | Hull | P Crossley |
| 04/12/2010 | Coventry | 1 | 0 | Middlesbrough | D Whitestone |
| 11/12/2010 | Middlesbrough | 1 | 0 | Cardiff | A Bates |
| 17/12/2010 | Doncaster | 2 | 1 | Middlesbrough | C Boyeson |
| 28/12/2010 | Preston | 1 | 3 | Middlesbrough | C Pawson |
| 01/01/2011 | Leeds | 1 | 1 | Middlesbrough | C Webster |
| 03/01/2011 | Middlesbrough | 1 | 1 | Norwich | G Salisbury |
| 15/01/2011 | Bristol City | 0 | 4 | Middlesbrough | D Drysdale |
| 22/01/2011 | Middlesbrough | 1 | 1 | Preston | M Russell |
| 01/02/2011 | Middlesbrough | 2 | 0 | Scunthorpe | R Lewis |
| 05/02/2011 | Crystal Palace | 1 | 0 | Middlesbrough | R East |
| 12/02/2011 | Middlesbrough | 3 | 4 | Swansea | R Madley |
| 19/02/2011 | Millwall | 2 | 3 | Middlesbrough | C Sarginson |
| 26/02/2011 | Middlesbrough | 0 | 3 | QPR | K Stroud |
| 01/03/2011 | Middlesbrough | 1 | 1 | Nott'm Forest | E Ilderton |
| 05/03/2011 | Reading | 5 | 2 | Middlesbrough | N Swarbrick |
| 08/03/2011 | Middlesbrough | 2 | 1 | Derby | K Evans |
| 12/03/2011 | Portsmouth | 0 | 0 | Middlesbrough | P Crossley |
| 19/03/2011 | Middlesbrough | 2 | 1 | Watford | G Sutton |
| 02/04/2011 | Middlesbrough | 3 | 3 | Leicester | A Haines |
| 09/04/2011 | Sheffield United | 1 | 2 | Middlesbrough | A Woolmer |
| 12/04/2011 | Ipswich | 3 | 3 | Middlesbrough | M Russell |
| 16/04/2011 | Middlesbrough | 1 | 1 | Barnsley | C Sarginson |
| 19/04/2011 | Burnley | 3 | 1 | Middlesbrough | M Haywood |
| 23/04/2011 | Hull | 2 | 4 | Middlesbrough | P Miller |
| 25/04/2011 | Middlesbrough | 2 | 1 | Coventry | G Ward |
| 02/05/2011 | Cardiff | 0 | 3 | Middlesbrough | G Scott |
| 07/05/2011 | Middlesbrough | 3 | 0 | Doncaster | I Williamson |