Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Stevenage | 2 | 2 | Macclesfield | D Phillips |
| 14/08/2010 | Macclesfield | 0 | 1 | Shrewsbury | M Haywood |
| 21/08/2010 | Accrington | 3 | 0 | Macclesfield | C Pawson |
| 28/08/2010 | Macclesfield | 1 | 1 | Chesterfield | P Gibbs |
| 04/09/2010 | Macclesfield | 0 | 2 | Stockport | D Foster |
| 11/09/2010 | Wycombe | 1 | 2 | Macclesfield | P Miller |
| 18/09/2010 | Macclesfield | 0 | 3 | Port Vale | M Oliver |
| 25/09/2010 | Torquay | 1 | 3 | Macclesfield | G Sutton |
| 28/09/2010 | Crewe | 1 | 1 | Macclesfield | G Salisbury |
| 02/10/2010 | Macclesfield | 2 | 0 | Northampton | R Booth |
| 09/10/2010 | Lincoln | 2 | 1 | Macclesfield | D Webb |
| 16/10/2010 | Macclesfield | 3 | 2 | Oxford | K Evans |
| 23/10/2010 | Barnet | 1 | 0 | Macclesfield | M Naylor |
| 30/10/2010 | Macclesfield | 2 | 1 | Burton | A Penn |
| 02/11/2010 | Rotherham | 1 | 1 | Macclesfield | N Miller |
| 13/11/2010 | Macclesfield | 2 | 0 | Aldershot | D Coote |
| 20/11/2010 | Bradford | 0 | 1 | Macclesfield | S Attwell |
| 23/11/2010 | Macclesfield | 0 | 2 | Cheltenham | M Naylor |
| 11/12/2010 | Macclesfield | 2 | 4 | Gillingham | K Hill |
| 28/12/2010 | Oxford | 2 | 1 | Macclesfield | R Lewis |
| 01/01/2011 | Bury | 2 | 2 | Macclesfield | P Quinn |
| 03/01/2011 | Macclesfield | 0 | 2 | Rotherham | E Ilderton |
| 22/01/2011 | Macclesfield | 1 | 1 | Barnet | P Tierney |
| 25/01/2011 | Southend | 4 | 1 | Macclesfield | M Russell |
| 01/02/2011 | Macclesfield | 2 | 4 | Bury | N Swarbrick |
| 08/02/2011 | Hereford | 2 | 2 | Macclesfield | K Stroud |
| 12/02/2011 | Aldershot | 0 | 0 | Macclesfield | R East |
| 19/02/2011 | Stockport | 1 | 4 | Macclesfield | C Boyeson |
| 22/02/2011 | Macclesfield | 2 | 0 | Morecambe | G Sutton |
| 26/02/2011 | Macclesfield | 0 | 1 | Wycombe | J Adcock |
| 05/03/2011 | Port Vale | 2 | 1 | Macclesfield | A Haines |
| 08/03/2011 | Macclesfield | 1 | 0 | Crewe | S Mathieson |
| 12/03/2011 | Northampton | 0 | 1 | Macclesfield | G Eltringham |
| 15/03/2011 | Macclesfield | 1 | 1 | Lincoln | C Sarginson |
| 19/03/2011 | Macclesfield | 3 | 3 | Torquay | G Salisbury |
| 22/03/2011 | Morecambe | 1 | 2 | Macclesfield | J Moss |
| 26/03/2011 | Macclesfield | 0 | 4 | Stevenage | E Ilderton |
| 30/03/2011 | Burton | 3 | 2 | Macclesfield | S Hooper |
| 02/04/2011 | Shrewsbury | 4 | 1 | Macclesfield | D Drysdale |
| 05/04/2011 | Macclesfield | 0 | 1 | Bradford | D Deadman |
| 08/04/2011 | Macclesfield | 2 | 2 | Accrington | S Rushton |
| 16/04/2011 | Chesterfield | 2 | 1 | Macclesfield | G Horwood |
| 23/04/2011 | Cheltenham | 0 | 1 | Macclesfield | F Graham |
| 25/04/2011 | Macclesfield | 0 | 0 | Southend | B Malone |
| 30/04/2011 | Gillingham | 2 | 4 | Macclesfield | C Sarginson |
| 07/05/2011 | Macclesfield | 1 | 1 | Hereford | J Linnington |