Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Yeovil | 2 | 1 | Leyton Orient | M Haywood |
| 13/08/2010 | Leyton Orient | 1 | 3 | Charlton | J Linnington |
| 21/08/2010 | Southampton | 1 | 1 | Leyton Orient | P Gibbs |
| 28/08/2010 | Leyton Orient | 3 | 0 | Exeter | P Miller |
| 04/09/2010 | Dag and Red | 2 | 0 | Leyton Orient | F Graham |
| 11/09/2010 | Leyton Orient | 1 | 2 | Huddersfield | A D'Urso |
| 18/09/2010 | Notts County | 3 | 2 | Leyton Orient | S Rushton |
| 24/09/2010 | Leyton Orient | 1 | 0 | Brentford | G Scott |
| 28/09/2010 | Leyton Orient | 0 | 0 | Walsall | K Stroud |
| 02/10/2010 | Oldham | 1 | 1 | Leyton Orient | R Madley |
| 09/10/2010 | Sheffield Weds | 1 | 0 | Leyton Orient | G Eltringham |
| 16/10/2010 | Leyton Orient | 1 | 0 | Hartlepool | D Coote |
| 23/10/2010 | Swindon | 2 | 2 | Leyton Orient | T Kettle |
| 30/10/2010 | Leyton Orient | 2 | 1 | Rochdale | K Wright |
| 02/11/2010 | Colchester | 3 | 2 | Leyton Orient | G Hegley |
| 13/11/2010 | Bristol Rvs | 0 | 3 | Leyton Orient | A Woolmer |
| 20/11/2010 | Leyton Orient | 2 | 2 | Bournemouth | K Hill |
| 23/11/2010 | Peterboro | 2 | 2 | Leyton Orient | B Malone |
| 11/12/2010 | Tranmere | 1 | 2 | Leyton Orient | M Russell |
| 01/01/2011 | Brighton | 5 | 0 | Leyton Orient | J Linington |
| 03/01/2011 | Leyton Orient | 4 | 2 | Colchester | D McDermid |
| 15/01/2011 | Rochdale | 1 | 1 | Leyton Orient | A Haines |
| 22/01/2011 | Leyton Orient | 4 | 0 | Sheffield Weds | O Langford |
| 25/01/2011 | Leyton Orient | 2 | 2 | Milton Keynes Dons | D Sheldrake |
| 01/02/2011 | Leyton Orient | 0 | 0 | Brighton | G Horwood |
| 05/02/2011 | Bournemouth | 1 | 1 | Leyton Orient | S Tanner |
| 08/02/2011 | Leyton Orient | 3 | 0 | Swindon | D Phillips |
| 12/02/2011 | Leyton Orient | 4 | 1 | Bristol Rvs | N Miller |
| 15/02/2011 | Milton Keynes Dons | 2 | 3 | Leyton Orient | B Malone |
| 26/02/2011 | Huddersfield | 2 | 2 | Leyton Orient | P Quinn |
| 05/03/2011 | Leyton Orient | 2 | 0 | Notts County | G Hegley |
| 08/03/2011 | Walsall | 0 | 2 | Leyton Orient | A Woolmer |
| 12/03/2011 | Leyton Orient | 1 | 0 | Oldham | R Lewis |
| 15/03/2011 | Hartlepool | 0 | 1 | Leyton Orient | J Moss |
| 19/03/2011 | Brentford | 2 | 1 | Leyton Orient | D Phillips |
| 22/03/2011 | Leyton Orient | 1 | 1 | Dag and Red | T Kettle |
| 26/03/2011 | Leyton Orient | 1 | 5 | Yeovil | G Eltringham |
| 02/04/2011 | Charlton | 3 | 1 | Leyton Orient | S Hooper |
| 05/04/2011 | Leyton Orient | 2 | 0 | Plymouth | M Naylor |
| 09/04/2011 | Leyton Orient | 0 | 2 | Southampton | M Clattenburg |
| 12/04/2011 | Leyton Orient | 0 | 0 | Carlisle | G Sutton |
| 16/04/2011 | Exeter | 2 | 1 | Leyton Orient | B Malone |
| 22/04/2011 | Leyton Orient | 2 | 1 | Peterboro | I Williamson |
| 25/04/2011 | Carlisle | 0 | 1 | Leyton Orient | M Brown |
| 30/04/2011 | Leyton Orient | 0 | 3 | Tranmere | G Horwood |
| 07/05/2011 | Plymouth | 1 | 4 | Leyton Orient | D Whitestone |