Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Hull | 2 | 0 | Swansea | M Russell |
| 14/08/2010 | Millwall | 4 | 0 | Hull | A Penn |
| 21/08/2010 | Hull | 0 | 0 | Watford | S Mathieson |
| 28/08/2010 | Doncaster | 3 | 1 | Hull | L Mason |
| 11/09/2010 | Cardiff | 2 | 0 | Hull | O Langford |
| 14/09/2010 | Hull | 2 | 0 | Derby | D Whitestone |
| 18/09/2010 | Hull | 0 | 0 | Nott'm Forest | M Halsey |
| 25/09/2010 | Norwich | 0 | 2 | Hull | D Foster |
| 28/09/2010 | Burnley | 4 | 0 | Hull | A Bates |
| 02/10/2010 | Hull | 0 | 0 | Coventry | S Rushton |
| 16/10/2010 | Leicester | 1 | 1 | Hull | N Miller |
| 19/10/2010 | Hull | 0 | 1 | Sheffield United | K Friend |
| 23/10/2010 | Hull | 1 | 2 | Portsmouth | D Deadman |
| 30/10/2010 | Barnsley | 1 | 1 | Hull | A D'Urso |
| 06/11/2010 | Hull | 0 | 1 | Scunthorpe | A Taylor |
| 09/11/2010 | Leeds | 2 | 2 | Hull | K Friend |
| 12/11/2010 | Preston | 0 | 2 | Hull | T Kettle |
| 20/11/2010 | Hull | 1 | 0 | Ipswich | A Haines |
| 27/11/2010 | Middlesbrough | 2 | 2 | Hull | P Crossley |
| 11/12/2010 | Crystal Palace | 0 | 0 | Hull | S Tanner |
| 18/12/2010 | Hull | 2 | 0 | Bristol City | C Webster |
| 26/12/2010 | Sheffield United | 2 | 3 | Hull | S Mathieson |
| 28/12/2010 | Hull | 1 | 1 | Reading | D Foster |
| 01/01/2011 | Hull | 0 | 1 | Leicester | D Webb |
| 03/01/2011 | Portsmouth | 2 | 3 | Hull | R Shoebridge |
| 15/01/2011 | Hull | 2 | 0 | Barnsley | P Quinn |
| 22/01/2011 | Reading | 1 | 1 | Hull | J Linington |
| 29/01/2011 | Hull | 0 | 0 | QPR | K Hill |
| 01/02/2011 | Hull | 2 | 2 | Leeds | G Salisbury |
| 05/02/2011 | Scunthorpe | 1 | 5 | Hull | M Haywood |
| 12/02/2011 | Hull | 1 | 0 | Preston | E Ilderton |
| 19/02/2011 | Ipswich | 1 | 1 | Hull | C Pawson |
| 22/02/2011 | Derby | 0 | 1 | Hull | A Woolmer |
| 26/02/2011 | Hull | 0 | 2 | Cardiff | P Tierney |
| 05/03/2011 | Nott'm Forest | 0 | 1 | Hull | S Hooper |
| 08/03/2011 | Hull | 0 | 1 | Burnley | D Deadman |
| 12/03/2011 | Coventry | 0 | 1 | Hull | S Tanner |
| 19/03/2011 | Hull | 1 | 1 | Norwich | R Shoebridge |
| 02/04/2011 | Hull | 0 | 1 | Millwall | A D'Urso |
| 09/04/2011 | Watford | 1 | 2 | Hull | D Phillips |
| 12/04/2011 | Swansea | 1 | 1 | Hull | R Booth |
| 16/04/2011 | Hull | 3 | 1 | Doncaster | M Clattenburg |
| 23/04/2011 | Hull | 2 | 4 | Middlesbrough | P Miller |
| 25/04/2011 | QPR | 1 | 1 | Hull | C Webster |
| 30/04/2011 | Hull | 1 | 1 | Crystal Palace | A Woolmer |
| 07/05/2011 | Bristol City | 3 | 0 | Hull | K Wright |