Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Rochdale | 0 | 0 | Hartlepool | A Penn |
| 14/08/2010 | Hartlepool | 2 | 2 | Swindon | C Boyeson |
| 21/08/2010 | Yeovil | 0 | 2 | Hartlepool | J Linington |
| 28/08/2010 | Hartlepool | 0 | 5 | Sheffield Weds | N Swarbrick |
| 04/09/2010 | Milton Keynes Dons | 1 | 0 | Hartlepool | C Pawson |
| 11/09/2010 | Hartlepool | 2 | 3 | Exeter | J Moss |
| 18/09/2010 | Brentford | 0 | 0 | Hartlepool | K Wright |
| 25/09/2010 | Hartlepool | 2 | 1 | Walsall | R Shoebridge |
| 28/09/2010 | Hartlepool | 0 | 4 | Carlisle | P Tierney |
| 02/10/2010 | Plymouth | 0 | 1 | Hartlepool | S Hooper |
| 09/10/2010 | Hartlepool | 2 | 0 | Peterboro | M Brown |
| 16/10/2010 | Leyton Orient | 1 | 0 | Hartlepool | D Coote |
| 23/10/2010 | Hartlepool | 2 | 2 | Bristol Rvs | M Haywood |
| 30/10/2010 | Dag and Red | 1 | 1 | Hartlepool | D Phillips |
| 13/11/2010 | Hartlepool | 3 | 1 | Brighton | R Booth |
| 20/11/2010 | Colchester | 3 | 2 | Hartlepool | O Langford |
| 23/11/2010 | Tranmere | 0 | 1 | Hartlepool | G Sutton |
| 11/12/2010 | Bournemouth | 0 | 1 | Hartlepool | D McDermid |
| 26/12/2010 | Huddersfield | 0 | 1 | Hartlepool | M Naylor |
| 01/01/2011 | Hartlepool | 4 | 2 | Oldham | A Haines |
| 03/01/2011 | Notts County | 3 | 0 | Hartlepool | D Drysdale |
| 15/01/2011 | Hartlepool | 0 | 1 | Dag and Red | K Evans |
| 18/01/2011 | Bristol Rvs | 0 | 0 | Hartlepool | D Sheldrake |
| 22/01/2011 | Peterboro | 4 | 0 | Hartlepool | R Lewis |
| 25/01/2011 | Hartlepool | 1 | 1 | Notts County | O Langford |
| 01/02/2011 | Oldham | 4 | 0 | Hartlepool | P Tierney |
| 05/02/2011 | Hartlepool | 1 | 0 | Colchester | T Kettle |
| 12/02/2011 | Brighton | 4 | 1 | Hartlepool | G Ward |
| 15/02/2011 | Hartlepool | 2 | 1 | Charlton | S Rushton |
| 19/02/2011 | Hartlepool | 0 | 1 | Milton Keynes Dons | G Sutton |
| 22/02/2011 | Hartlepool | 0 | 0 | Southampton | S Mathieson |
| 26/02/2011 | Exeter | 1 | 2 | Hartlepool | C Sarginson |
| 01/03/2011 | Hartlepool | 0 | 1 | Huddersfield | D Coote |
| 05/03/2011 | Hartlepool | 3 | 0 | Brentford | K Evans |
| 08/03/2011 | Carlisle | 1 | 0 | Hartlepool | R Booth |
| 12/03/2011 | Hartlepool | 2 | 0 | Plymouth | C Pawson |
| 15/03/2011 | Hartlepool | 0 | 1 | Leyton Orient | J Moss |
| 19/03/2011 | Walsall | 5 | 2 | Hartlepool | N Swarbrick |
| 25/03/2011 | Hartlepool | 0 | 2 | Rochdale | M Brown |
| 02/04/2011 | Swindon | 1 | 1 | Hartlepool | P Miller |
| 09/04/2011 | Hartlepool | 3 | 1 | Yeovil | P Tierney |
| 16/04/2011 | Sheffield Weds | 2 | 0 | Hartlepool | G Ward |
| 22/04/2011 | Hartlepool | 1 | 1 | Tranmere | M Haywood |
| 25/04/2011 | Southampton | 2 | 0 | Hartlepool | S Hooper |
| 30/04/2011 | Hartlepool | 2 | 2 | Bournemouth | J Waugh |
| 07/05/2011 | Charlton | 0 | 0 | Hartlepool | K Stroud |