Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Leeds | 1 | 2 | Derby | N Swarbrick |
| 14/08/2010 | Derby | 1 | 2 | Cardiff | N Miller |
| 21/08/2010 | Coventry | 2 | 1 | Derby | E Ilderton |
| 28/08/2010 | Derby | 2 | 2 | QPR | M Haywood |
| 11/09/2010 | Derby | 0 | 1 | Sheffield United | P Crossley |
| 14/09/2010 | Hull | 2 | 0 | Derby | D Whitestone |
| 18/09/2010 | Barnsley | 1 | 1 | Derby | D Webb |
| 25/09/2010 | Derby | 5 | 0 | Crystal Palace | A Bates |
| 28/09/2010 | Derby | 3 | 1 | Middlesbrough | C Pawson |
| 02/10/2010 | Swansea | 0 | 0 | Derby | P Gibbs |
| 16/10/2010 | Derby | 3 | 0 | Preston | A D'Urso |
| 19/10/2010 | Doncaster | 2 | 3 | Derby | K Evans |
| 23/10/2010 | Millwall | 2 | 0 | Derby | G Salisbury |
| 30/10/2010 | Derby | 4 | 1 | Watford | P Tierney |
| 06/11/2010 | Derby | 2 | 0 | Portsmouth | C Webster |
| 09/11/2010 | Ipswich | 0 | 2 | Derby | R East |
| 13/11/2010 | Leicester | 2 | 0 | Derby | S Tanner |
| 20/11/2010 | Derby | 3 | 2 | Scunthorpe | J Linington |
| 27/11/2010 | Burnley | 2 | 1 | Derby | M Haywood |
| 04/12/2010 | Derby | 1 | 2 | Norwich | K Stroud |
| 11/12/2010 | Bristol City | 2 | 0 | Derby | D Sheldrake |
| 18/12/2010 | Derby | 1 | 2 | Reading | D Deadman |
| 29/12/2010 | Nott'm Forest | 5 | 2 | Derby | A Bates |
| 01/01/2011 | Preston | 1 | 2 | Derby | R Madley |
| 03/01/2011 | Derby | 0 | 0 | Millwall | K Wright |
| 15/01/2011 | Watford | 3 | 0 | Derby | G Ward |
| 22/01/2011 | Derby | 0 | 1 | Nott'm Forest | G Salisbury |
| 01/02/2011 | Derby | 1 | 2 | Ipswich | C Boyeson |
| 05/02/2011 | Portsmouth | 1 | 1 | Derby | N Swarbrick |
| 12/02/2011 | Derby | 0 | 2 | Leicester | C Webster |
| 19/02/2011 | Scunthorpe | 0 | 0 | Derby | S Mathieson |
| 22/02/2011 | Derby | 0 | 1 | Hull | A Woolmer |
| 26/02/2011 | Sheffield United | 0 | 1 | Derby | R East |
| 01/03/2011 | Derby | 1 | 3 | Doncaster | K Hill |
| 05/03/2011 | Derby | 0 | 0 | Barnsley | D Deadman |
| 08/03/2011 | Middlesbrough | 2 | 1 | Derby | K Evans |
| 12/03/2011 | Derby | 2 | 1 | Swansea | G Scott |
| 19/03/2011 | Crystal Palace | 2 | 2 | Derby | J Moss |
| 02/04/2011 | Cardiff | 4 | 1 | Derby | J Linington |
| 09/04/2011 | Derby | 2 | 2 | Coventry | R Booth |
| 12/04/2011 | Derby | 2 | 1 | Leeds | G Salisbury |
| 18/04/2011 | QPR | 0 | 0 | Derby | D Deadman |
| 23/04/2011 | Derby | 2 | 4 | Burnley | M Russell |
| 25/04/2011 | Norwich | 3 | 2 | Derby | A Haines |
| 30/04/2011 | Derby | 0 | 2 | Bristol City | I Williamson |
| 07/05/2011 | Reading | 2 | 1 | Derby | P Miller |