Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Crewe | 0 | 1 | Hereford | B Malone |
| 14/08/2010 | Cheltenham | 3 | 2 | Crewe | I Williamson |
| 21/08/2010 | Crewe | 7 | 0 | Barnet | R Madley |
| 28/08/2010 | Lincoln | 1 | 1 | Crewe | D Foster |
| 04/09/2010 | Stevenage | 1 | 1 | Crewe | J Linington |
| 11/09/2010 | Crewe | 3 | 0 | Bury | J Waugh |
| 18/09/2010 | Burton | 1 | 1 | Crewe | M Brown |
| 25/09/2010 | Crewe | 1 | 1 | Oxford | G Eltringham |
| 28/09/2010 | Crewe | 1 | 1 | Macclesfield | G Salisbury |
| 02/10/2010 | Chesterfield | 5 | 5 | Crewe | J Moss |
| 09/10/2010 | Crewe | 3 | 3 | Torquay | R Booth |
| 16/10/2010 | Southend | 0 | 2 | Crewe | A Woolmer |
| 23/10/2010 | Crewe | 3 | 1 | Aldershot | A Haines |
| 30/10/2010 | Port Vale | 2 | 1 | Crewe | A Taylor |
| 02/11/2010 | Crewe | 1 | 2 | Shrewsbury | K Evans |
| 13/11/2010 | Gillingham | 1 | 3 | Crewe | D Phillips |
| 20/11/2010 | Crewe | 0 | 1 | Rotherham | N Swarbrick |
| 27/11/2010 | Morecambe | 1 | 2 | Crewe | D Drysdale |
| 11/12/2010 | Stockport | 3 | 3 | Crewe | S Attwell |
| 01/01/2011 | Crewe | 2 | 0 | Northampton | C Pawson |
| 03/01/2011 | Shrewsbury | 0 | 1 | Crewe | G Horwood |
| 08/01/2011 | Crewe | 3 | 0 | Wycombe | S Hooper |
| 11/01/2011 | Torquay | 2 | 1 | Crewe | J Linington |
| 15/01/2011 | Crewe | 2 | 1 | Port Vale | S Tanner |
| 22/01/2011 | Aldershot | 3 | 2 | Crewe | K Stroud |
| 25/01/2011 | Crewe | 2 | 1 | Bradford | K Wright |
| 01/02/2011 | Northampton | 6 | 2 | Crewe | A Madley |
| 05/02/2011 | Rotherham | 3 | 1 | Crewe | D Foster |
| 12/02/2011 | Crewe | 1 | 1 | Gillingham | K Evans |
| 19/02/2011 | Crewe | 0 | 1 | Stevenage | S Rushton |
| 22/02/2011 | Accrington | 3 | 2 | Crewe | P Tierney |
| 26/02/2011 | Bury | 3 | 1 | Crewe | M Haywood |
| 05/03/2011 | Crewe | 4 | 1 | Burton | C Webster |
| 08/03/2011 | Macclesfield | 1 | 0 | Crewe | S Mathieson |
| 12/03/2011 | Crewe | 2 | 0 | Chesterfield | G Ward |
| 15/03/2011 | Crewe | 1 | 0 | Southend | G Eltringham |
| 19/03/2011 | Oxford | 2 | 1 | Crewe | C Boyeson |
| 22/03/2011 | Crewe | 0 | 0 | Accrington | D Coote |
| 27/03/2011 | Hereford | 1 | 0 | Crewe | G Sutton |
| 02/04/2011 | Crewe | 8 | 1 | Cheltenham | P Quinn |
| 09/04/2011 | Barnet | 2 | 1 | Crewe | M Brown |
| 16/04/2011 | Crewe | 1 | 1 | Lincoln | P Miller |
| 22/04/2011 | Crewe | 2 | 1 | Morecambe | C Sarginson |
| 25/04/2011 | Wycombe | 2 | 0 | Crewe | D McDermid |
| 30/04/2011 | Crewe | 2 | 0 | Stockport | A Bates |
| 07/05/2011 | Bradford | 1 | 5 | Crewe | G Salisbury |