Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Gillingham | 1 | 1 | Cheltenham | P Crossley |
| 14/08/2010 | Cheltenham | 3 | 2 | Crewe | I Williamson |
| 21/08/2010 | Rotherham | 6 | 4 | Cheltenham | P Tierney |
| 28/08/2010 | Cheltenham | 2 | 1 | Burton | R East |
| 04/09/2010 | Barnet | 3 | 1 | Cheltenham | G Sutton |
| 11/09/2010 | Cheltenham | 1 | 0 | Stevenage | C Boyeson |
| 18/09/2010 | Chesterfield | 3 | 0 | Cheltenham | R Madley |
| 25/09/2010 | Cheltenham | 0 | 2 | Bury | G Ward |
| 28/09/2010 | Cheltenham | 1 | 1 | Oxford | S Rushton |
| 02/10/2010 | Aldershot | 0 | 2 | Cheltenham | O Langford |
| 09/10/2010 | Cheltenham | 1 | 0 | Northampton | D Phillips |
| 16/10/2010 | Bradford | 3 | 1 | Cheltenham | D Drysdale |
| 23/10/2010 | Cheltenham | 0 | 0 | Port Vale | D Whitestone |
| 30/10/2010 | Accrington | 2 | 4 | Cheltenham | R Lewis |
| 13/11/2010 | Hereford | 1 | 1 | Cheltenham | G Salisbury |
| 20/11/2010 | Cheltenham | 1 | 1 | Morecambe | D Sheldrake |
| 23/11/2010 | Macclesfield | 0 | 2 | Cheltenham | M Naylor |
| 11/12/2010 | Shrewsbury | 1 | 1 | Cheltenham | G Ward |
| 14/12/2010 | Cheltenham | 0 | 2 | Southend | B Malone |
| 28/12/2010 | Cheltenham | 4 | 0 | Bradford | C Sarginson |
| 01/01/2011 | Cheltenham | 1 | 2 | Wycombe | G Scott |
| 03/01/2011 | Southend | 1 | 2 | Cheltenham | P Gibbs |
| 08/01/2011 | Northampton | 1 | 1 | Cheltenham | S Rushton |
| 15/01/2011 | Cheltenham | 1 | 2 | Accrington | M Russell |
| 22/01/2011 | Port Vale | 0 | 1 | Cheltenham | P Tierney |
| 25/01/2011 | Cheltenham | 1 | 2 | Lincoln | A Taylor |
| 29/01/2011 | Oxford | 1 | 1 | Cheltenham | G Horwood |
| 01/02/2011 | Wycombe | 2 | 1 | Cheltenham | S Tanner |
| 05/02/2011 | Morecambe | 1 | 1 | Cheltenham | S Martin |
| 12/02/2011 | Cheltenham | 0 | 3 | Hereford | O Langford |
| 19/02/2011 | Cheltenham | 1 | 1 | Barnet | R Shoebridge |
| 22/02/2011 | Cheltenham | 2 | 2 | Torquay | A Bates |
| 26/02/2011 | Stevenage | 4 | 0 | Cheltenham | D Sheldrake |
| 01/03/2011 | Cheltenham | 2 | 1 | Stockport | R Booth |
| 05/03/2011 | Cheltenham | 0 | 3 | Chesterfield | P Tierney |
| 12/03/2011 | Cheltenham | 1 | 2 | Aldershot | K Wright |
| 19/03/2011 | Bury | 2 | 3 | Cheltenham | R East |
| 22/03/2011 | Torquay | 2 | 1 | Cheltenham | S Tanner |
| 27/03/2011 | Cheltenham | 1 | 2 | Gillingham | N Miller |
| 02/04/2011 | Crewe | 8 | 1 | Cheltenham | P Quinn |
| 09/04/2011 | Cheltenham | 1 | 1 | Rotherham | I Williamson |
| 16/04/2011 | Burton | 2 | 0 | Cheltenham | D Foster |
| 23/04/2011 | Cheltenham | 0 | 1 | Macclesfield | F Graham |
| 25/04/2011 | Lincoln | 0 | 2 | Cheltenham | K Evans |
| 30/04/2011 | Cheltenham | 0 | 1 | Shrewsbury | M Brown |
| 07/05/2011 | Stockport | 1 | 1 | Cheltenham | D Phillips |