Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Charlton | 1 | 0 | Bournemouth | G Hegley |
| 13/08/2010 | Leyton Orient | 1 | 3 | Charlton | J Linnington |
| 21/08/2010 | Charlton | 1 | 1 | Oldham | R Shoebridge |
| 28/08/2010 | Huddersfield | 3 | 1 | Charlton | G Salisbury |
| 04/09/2010 | Exeter | 1 | 0 | Charlton | D Phillips |
| 11/09/2010 | Charlton | 1 | 0 | Notts County | P Tierney |
| 18/09/2010 | Tranmere | 1 | 1 | Charlton | P Gibbs |
| 25/09/2010 | Charlton | 2 | 2 | Dag and Red | J Moss |
| 28/09/2010 | Charlton | 1 | 0 | Milton Keynes Dons | J Waugh |
| 02/10/2010 | Brentford | 2 | 1 | Charlton | A Penn |
| 09/10/2010 | Plymouth | 2 | 2 | Charlton | C Sarginson |
| 16/10/2010 | Charlton | 0 | 4 | Brighton | N Swarbrick |
| 23/10/2010 | Carlisle | 3 | 4 | Charlton | S Mathieson |
| 30/10/2010 | Charlton | 1 | 0 | Sheffield Weds | R East |
| 02/11/2010 | Swindon | 0 | 3 | Charlton | R Booth |
| 13/11/2010 | Peterboro | 1 | 5 | Charlton | D Foster |
| 20/11/2010 | Charlton | 3 | 2 | Yeovil | D Whitestone |
| 23/11/2010 | Charlton | 1 | 1 | Bristol Rvs | M Russell |
| 12/12/2010 | Charlton | 0 | 1 | Walsall | C Pawson |
| 29/12/2010 | Brighton | 1 | 1 | Charlton | D Deadman |
| 01/01/2011 | Colchester | 3 | 3 | Charlton | P Miller |
| 03/01/2011 | Charlton | 2 | 4 | Swindon | A Woolmer |
| 15/01/2011 | Sheffield Weds | 2 | 2 | Charlton | C Boyeson |
| 22/01/2011 | Charlton | 2 | 0 | Plymouth | F Graham |
| 01/02/2011 | Charlton | 1 | 0 | Colchester | D Sheldrake |
| 05/02/2011 | Yeovil | 0 | 1 | Charlton | K Evans |
| 12/02/2011 | Charlton | 3 | 2 | Peterboro | D Webb |
| 15/02/2011 | Hartlepool | 2 | 1 | Charlton | S Rushton |
| 19/02/2011 | Charlton | 1 | 3 | Exeter | S Tanner |
| 25/02/2011 | Notts County | 1 | 0 | Charlton | J Moss |
| 01/03/2011 | Charlton | 1 | 3 | Carlisle | D McDermid |
| 05/03/2011 | Charlton | 1 | 1 | Tranmere | D Coote |
| 08/03/2011 | Milton Keynes Dons | 2 | 0 | Charlton | K Stroud |
| 12/03/2011 | Charlton | 0 | 1 | Brentford | M Russell |
| 19/03/2011 | Dag and Red | 2 | 1 | Charlton | I Williamson |
| 22/03/2011 | Charlton | 1 | 1 | Southampton | A D'Urso |
| 26/03/2011 | Bournemouth | 2 | 2 | Charlton | M Haywood |
| 29/03/2011 | Rochdale | 2 | 0 | Charlton | E Ilderton |
| 02/04/2011 | Charlton | 3 | 1 | Leyton Orient | S Hooper |
| 05/04/2011 | Southampton | 2 | 0 | Charlton | A Bates |
| 09/04/2011 | Oldham | 0 | 0 | Charlton | K Wright |
| 16/04/2011 | Charlton | 0 | 1 | Huddersfield | O Langford |
| 23/04/2011 | Bristol Rvs | 2 | 2 | Charlton | R Lewis |
| 25/04/2011 | Charlton | 3 | 1 | Rochdale | P Miller |
| 30/04/2011 | Walsall | 2 | 0 | Charlton | G Eltringham |
| 07/05/2011 | Charlton | 0 | 0 | Hartlepool | K Stroud |