Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Carlisle | 2 | 0 | Brentford | A Haines |
| 14/08/2010 | Plymouth | 1 | 1 | Carlisle | R East |
| 21/08/2010 | Carlisle | 4 | 1 | Milton Keynes Dons | M Haywood |
| 27/08/2010 | Colchester | 1 | 1 | Carlisle | G Ward |
| 04/09/2010 | Carlisle | 0 | 0 | Swindon | N Miller |
| 11/09/2010 | Sheffield Weds | 0 | 1 | Carlisle | C Sarginson |
| 18/09/2010 | Carlisle | 0 | 0 | Brighton | J Waugh |
| 25/09/2010 | Bournemouth | 2 | 0 | Carlisle | D Phillips |
| 28/09/2010 | Hartlepool | 0 | 4 | Carlisle | P Tierney |
| 02/10/2010 | Carlisle | 0 | 1 | Peterboro | P Quinn |
| 09/10/2010 | Carlisle | 1 | 0 | Notts County | M Naylor |
| 16/10/2010 | Exeter | 2 | 1 | Carlisle | S Rushton |
| 23/10/2010 | Carlisle | 3 | 4 | Charlton | S Mathieson |
| 30/10/2010 | Bristol Rvs | 1 | 1 | Carlisle | O Langford |
| 02/11/2010 | Carlisle | 2 | 0 | Tranmere | E Ilderton |
| 13/11/2010 | Carlisle | 3 | 2 | Southampton | K Evans |
| 20/11/2010 | Walsall | 2 | 1 | Carlisle | B Malone |
| 23/11/2010 | Carlisle | 1 | 1 | Rochdale | N Swarbrick |
| 11/12/2010 | Carlisle | 0 | 2 | Dag and Red | C Boyeson |
| 01/01/2011 | Carlisle | 2 | 2 | Huddersfield | G Eltringham |
| 03/01/2011 | Tranmere | 2 | 1 | Carlisle | D Foster |
| 15/01/2011 | Carlisle | 4 | 0 | Bristol Rvs | P Tierney |
| 22/01/2011 | Notts County | 0 | 1 | Carlisle | A Bates |
| 29/01/2011 | Carlisle | 2 | 2 | Oldham | C Pawson |
| 01/02/2011 | Huddersfield | 2 | 0 | Carlisle | D Deadman |
| 05/02/2011 | Carlisle | 1 | 3 | Walsall | C Webster |
| 12/02/2011 | Southampton | 1 | 0 | Carlisle | R Lewis |
| 15/02/2011 | Oldham | 0 | 1 | Carlisle | M Haywood |
| 19/02/2011 | Swindon | 0 | 1 | Carlisle | D Whitestone |
| 22/02/2011 | Carlisle | 2 | 2 | Exeter | A Haines |
| 26/02/2011 | Carlisle | 0 | 1 | Sheffield Weds | D Coote |
| 01/03/2011 | Charlton | 1 | 3 | Carlisle | D McDermid |
| 05/03/2011 | Brighton | 4 | 3 | Carlisle | O Langford |
| 08/03/2011 | Carlisle | 1 | 0 | Hartlepool | R Booth |
| 12/03/2011 | Peterboro | 6 | 0 | Carlisle | T Kettle |
| 15/03/2011 | Carlisle | 1 | 1 | Plymouth | N Swarbrick |
| 19/03/2011 | Carlisle | 1 | 0 | Bournemouth | R Madley |
| 25/03/2011 | Brentford | 2 | 1 | Carlisle | R East |
| 29/03/2011 | Yeovil | 1 | 0 | Carlisle | G Horwood |
| 09/04/2011 | Milton Keynes Dons | 3 | 2 | Carlisle | A D'Urso |
| 12/04/2011 | Leyton Orient | 0 | 0 | Carlisle | G Sutton |
| 16/04/2011 | Carlisle | 4 | 1 | Colchester | P Quinn |
| 23/04/2011 | Rochdale | 2 | 3 | Carlisle | S Rushton |
| 25/04/2011 | Carlisle | 0 | 1 | Leyton Orient | M Brown |
| 30/04/2011 | Dag and Red | 3 | 0 | Carlisle | D Drysdale |
| 07/05/2011 | Carlisle | 0 | 2 | Yeovil | J Waugh |